Pictures taken at the scene show a pickup truck in the ditch, its roof cut off and lying nearby. Another pickup sits on the shoulder of the highway, its front end smashed in.
The accident occurred just after 9:30 a.m. and the Deer Lake Detachment of the Royal Canadian Mounted Police said two other people were taken to hospital with injuries.
The RCMP did not provide any information on the ages or genders of those involved.
Traffic in the area was delayed throughout the day as crews with the Department of Transportation and Works cleared the debris that had been scattered across the highway.
The investigation into the accident is continuing, and late in the afternoon police said no other information would be released at that time.